Adherence to Mediterranean Diet: Any Association with NAFLD?

Oxidative stress is considered one of the main determinants in pathophysiology non-alcoholic fatty liver disease (NAFLD) and obesity. The alterations oxidant/antioxidant balance are related to chronic impairment metabolism leading mitochondrial dysfunction. Increased oxidative also triggers hepatocytes pathways, inflammation contributing progression steatohepatitis (NASH). Currently, first-line therapeutic treatment NAFLD based on lifestyle interventions, suggesting Mediterranean Diet (MD) as a preferable nutritional approach due its antioxidant properties. However, it still debated if adherence MD could have role determining risk developing directly or indirectly through effect weight. We enrolled 336 subjects (aged 35.87 ± 10.37 years; BMI 31.18 9.66 kg/m2) assessing anthropometric parameters, habits, metabolic parameters (fasting plasma glucose, fasting insulin, triglycerides (TG), total cholesterol, low-density (LDL) high-density lipoprotein (HDL) alanine transaminase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (γGT), cardio-metabolic indices [Homeostatic Model Assessment Insulin Resistance (HoMA-IR), visceral adipose index (VAI) (FLI)] [with PREvención con DIetaMEDiterránea (PREDIMED) questionnaire]. Subjects with had significantly higher lower than without NAFLD. In multiple regression analysis, PREDIMED score was predictor FLI (p < 0.001) came first, followed by HoMA-IR, while VAI not predictor. A value <6 serve threshold identify patients who more likely 0.001). conclusion, high resulted having Adherence direct NAFLD, regardless tissue.